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REACTOME is an open-source, open access, manually curated and peer-reviewed pathway database. Pathway annotations are authored by expert biologists, in collaboration with Reactome editorial staff and cross-referenced to many bioinformatics databases. These include NCBI Gene, Ensembl and UniProt databases, the UCSC and HapMap Genome Browsers, the KEGG Compound and ChEBI small molecule databases, PubMed, and Gene Ontology.

The rationale behind Reactome is to convey the rich information in the visual representations of biological pathways familiar from textbooks and articles in a detailed, computationally accessible format. The core unit of the Reactome data model is the reaction. Entities (nucleic acids, proteins, complexes and small molecules) participating in reactions form a network of biological interactions and are grouped into pathways. Examples of biological pathways in Reactome include signaling, innate and acquired immune function, transcriptional regulation, translation, apoptosis and classical intermediary metabolism.

The contents of Reactome are copyright (c) 2003-2012 Cold Spring Harbor Laboratory (CSHL), Ontario Institute for Cancer Research (OICR) and the European Bioinformatics Institute (EBI). The software and information contents are distributed under the terms of the Creative Commons Attribution 3.0 Unported License, which grants parties the non-exclusive right to use, distribute and create derivative works based on Reactome, provided that the software and information is correctly attributed to CSHL, OICR and EBI.

178 diagrams have been imported from this database into the BioUML platform. They can be used as graphical and editable schemata. In the repository pane, all components are listed in each diagram subdirectory.

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