Optimization examples

Here we give some examples of BioUML using for solving the problem of parameter estimation applied to the models of biochemical pathways. For details about creation your oun optimization document in BioUML, see the chapter Optimization document. Some information about the optimization methods implemented in BioUML is done in the chapter Optimization problem.

The model of p53 and Mdm2 interactions

ID Reactions Reaction rates r1 → p53 βx r2 -p53 → pMdm2 x r3 pMdm2 → Mdm2 α0 · y0 r4 p53 -Mdm2 → αxy · x · y r5 Mdm2 → αy · y