Manual parameter fitting

Manual parameter fitting is a tool providing user with convenient interface to manually tweak model parameters and observe changed simulation result.

To open this interface right click on diagram in repository tree and select New Simulation Document. Please note that opening of the document may take a while because it will simulate the model until completion time. Simulation document also uses plot settings from the diagram. To learn how to change plot settings refer to Systems biology - model simulation page.

To work with manual fitting go to tab Simulation editor. Here we will use one of the example models for optimization which can be found here.

For change model parameter - select it in the table and press one of next buttons:

• Reset parameter - resets initial value of selected parameter to default.
• Increase parameter - increases initial value of selected parameter by Step value.
• Decrease parameter - decreases initial value of selected parameter by Step value.

Simulation result will be updated automatically.

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  Figure 1: Manual fitting of parameter k12.

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  Figure 2: Manual fitting of parameter k12.

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  Figure 3: Manual fitting of parameter k12.

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  Figure 4: Manual fitting of parameter k12.

Additional functional: User may also change Value or Step for any parameter in the table. After changing the value press Run simulation to update simulation result with new parameter values. Button Save parameters to diagram saves all changes to parameters to the diagram. It also updates default values to current values. Button Reload parameters from diagram resets all changes made to parameters, also resets default values.