Difference between revisions of "PharmML"

Revision as of 23:46, 11 February 2014

PharmML - Pharmacometrics Markup Language - is a new standard for encoding of models, associated tasks and their annotation as used in pharmacometrics.

http://pharmml.org/ http://ddmore.eu/pharmml

It was developed by DDMoRe consortium.

The current version supports non-linear mixed effect models as used in analysis of continuous longitudinal population PK/PD data with:

• A structural model defined as a system of ordinary differential equation (ODE) and/or algebraic equations.
• A flexible parameter model allowing for implementation of virtually any parameter type used in the majority of models.
• Discrete or continuous covariates.
• A nested hierarchical variability model capable of expressing very complex random error structures.
• An observation model with flexible residual error model supporting untransformed or transformed data.
• A novel trial design model allowing for
  • definition of many common design and drug administration types
  • encoding of experimental data needed for typical simulation or estimation tasks, such as dosing, observations and covariates.
• Typical modelling steps such as estimation or simulation.