Difference between revisions of "Patient-specific cardiovascular model"

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This page was created to support article "Patient-specific model of the human cardiovascular system" sumbitted to 2015 International Conference on Biomedical Engineering and Computational Technologies (SIBIRCON) ([[www.soramn.ru/sibmedinfo/]]).
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This page was created to support article "Patient-specific model of the human cardiovascular system" sumbitted to 2015 International Conference on Biomedical Engineering and Computational Technologies [http://www.soramn.ru/sibmedinfo/ SIBIRCON].
  
 
Article describes personalization procedure of [[1-dimensional arterial tree model]] validated against a set of data on ~1200 individuals.
 
Article describes personalization procedure of [[1-dimensional arterial tree model]] validated against a set of data on ~1200 individuals.
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For personalization procedure model was updated with 4 new vessels and new function for input blood flow calculations. This version of the model is available [http://ie.biouml.org/bioumlweb/#de=databases/Patient-specific%20CVS%20models/Diagrams/Arterial%20Tree here].
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==Simulation results==
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<center>
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Table 1. Simulation results for a. brachialis sinistra (left brachial artery)
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{| class="wikitable"
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! rowspan = "2" |Parameters !! colspan = "3" |Correlations !! colspan="3" |Mean relative error
 +
|-
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!|Ps||Pd||Pp||Ps||Pd||Pp
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|-
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!! colspan = "7" |With personalization of TPR
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|-
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|TPR A0 β SV HR||0,7841||0,8641||0,011||0,055||0,208||0,372
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|-
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|TPR SV HR||0,8971||0,9251||-0,070||0,041||0,164||0,283
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|-
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|TPR HR||0,4841||0,5561||-0,3182||0,169||0,391||0,214
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|-
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|TPR SV||0,4221||0,5301||-0,075||0,119||0,249||0,283
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|-
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|TPR A0β||0,6931||0,7811||0,006||0,158||0,472||0,328
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|-
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|TPR A0||0,5691||0,8381||-0,1252||0,209||0,385||0,285
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|-
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|TPR β||0,8061||0,7591||0,0852||0,123||0,486||0,400
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|-
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|TPR||0,8101||0,8381||-0,4011||0,164||0,425||0,210
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|-
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!! colspan = "7" |Without personalization iof TPR
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|-
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|A0 β SV HR||0,007||-0,1621||0,046||0,171||0,126||0,342
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|-
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|SV HR||-0,060||-0,012||0,014||0,165||0,129||0,253
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|-
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|HR||0,034||0,077||-0,020||0,122||0,189||0,177
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|-
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|SV||-0,035||-0,073||0,019||0,167||0,161||0,252
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|-
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|A0 β||0,080||-0,226||0,051||0,092||0,181||0,301
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|-
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|A0||-0,1451||0,1501||-0,0922||0,113||0,120||0,283
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|-
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|β||0,2941||-0,2971||0,1372||0,086||0,195||0,365
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|}
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Table 2. Simulation results for right brachial arterty and lower limbs. In total – 556 individuals
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{| class="wikitable"
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! rowspan = "2" |Parameters !! colspan = "3" |Correlations !! colspan="3" |Mean relative error
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|-
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!Ps||Pd||Pp||Ps||Pd||Pp
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|-
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!! colspan = "7" |a. brachialis dextra
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|-
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|R A0 β SV HR||0,6811||0,7531||-0,0452||0,064||0,202||0,288
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|-
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|R SV HR||0,8171||0,8171||-0,120||0,051||0,164||0,205
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|-
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!! colspan = "7" |a. tibialis posterior sinistra
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|-
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|R A0 β SV HR||0,6661||0,6441||0,0912||0,246||0,095||0,493
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|-
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|R SV HR||0,5721||0,6401||-0,001||0,187||0,093||0,346
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|-
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!! colspan = "7" |a. tibialis posterior dextra
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|-
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|R A0 β SV HR||0,6161||0,6261||0,0872||0,248||0,098||0,492
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|-
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|R SV HR||0,5681||0,6501||-0,026||0,193||0,087||0,375
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|}
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Table 3. Simulation results for different allometric equations used for minute output. All parameters were personalized:  R, A0, β, SV, HR. In total – 556 individuals
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{| class="wikitable"
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! rowspan = "2" |Allometric equation !! colspan = "3" |Correlations !! colspan="3" |Mean relative error
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|-
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!|Ps||Pd||Pp||Ps||Pd||Pp
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|-
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|0,7691||0,8481||-0,0002||0,054||0,199||0,343
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|-
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|0,7501||0,8311||-0,015||0,056||0,192||0,328
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|-
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|0,7821||0,8641||0,011||0,055||0,208||0,372
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|-
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|0,7591||0,8421||-0,006||0,055||0,197||0,338
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|}
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Table 4. Simulation results with different model time. In each simulation last 2 seconds were used to obserev minimal and maximal ressures produced by the model
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{| class="wikitable"
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! rowspan = "2" |Model time !! colspan = "3" |Correlations !! colspan="3" |Mean relative error
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|-
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!|Ps||Pd||Pp||Ps||Pd||Pp
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|-
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|6 секунд||0,7531||0,8671||0,031||0,058||0,197||0,364
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|-
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|12 секунд||0,7841||0,8641||0,011||0,055||0,208||0,372
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|-
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|20 секунд||0,7891||0,8621||0,008||0,055||0,209||0,373
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|}
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Table 5. Simulation results for different age groups. Only TPR was personalized.
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{| class="wikitable"
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! rowspan = "2" |Age !! #!!colspan = "3" |Correlations !! colspan="3" |Mean relative error
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|-
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!|Ps||Pd||Pp||Ps||Pd||Pp
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|-
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|<=30||24||0,9441||0,9641||0,257||0,043||0,195||0,306
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|-
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|(30,50]||42||0,8421||0,8841||0,121||0,032||0,152||0,231
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|-
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|(50,60]||178||0,8921||0,9371||-0,003||0,036||0,152||0,247
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|-
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|(60,70]||246||0,9081||0,9311||-0,010||0,040||0,162||0,289
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|-
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|(70,80]||181||0,8771||0,8961||-0,137||0,051||0,171||0,307
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|}
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Table 6. Simulation results for control group (observation were recorded before 1 of May 1999)
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{| class="wikitable"
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! rowspan = "2" |Observation date !! #!!colspan = "3" |Correlations !! colspan="3" |Mean relative error
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|-
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!|Ps||Pd||Pp||Ps||Pd||Pp
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|-
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|Before 01.05.1999||420||0,7331||0,8011||0,1112||0,073||0,199||0,335
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|-
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|After 01.05.1999||556||0,7841||0,8641||0,011||0,055||0,208||0,372
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|-
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|Any||976||0,7541||0,8361||0,098||0,062||0,205||0,356
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|}

Latest revision as of 15:08, 25 September 2015

This page was created to support article "Patient-specific model of the human cardiovascular system" sumbitted to 2015 International Conference on Biomedical Engineering and Computational Technologies SIBIRCON.

Article describes personalization procedure of 1-dimensional arterial tree model validated against a set of data on ~1200 individuals.

For personalization procedure model was updated with 4 new vessels and new function for input blood flow calculations. This version of the model is available here.

[edit] Simulation results

Table 1. Simulation results for a. brachialis sinistra (left brachial artery)

Parameters Correlations Mean relative error
Ps Pd Pp Ps Pd Pp
With personalization of TPR
TPR A0 β SV HR 0,7841 0,8641 0,011 0,055 0,208 0,372
TPR SV HR 0,8971 0,9251 -0,070 0,041 0,164 0,283
TPR HR 0,4841 0,5561 -0,3182 0,169 0,391 0,214
TPR SV 0,4221 0,5301 -0,075 0,119 0,249 0,283
TPR A0β 0,6931 0,7811 0,006 0,158 0,472 0,328
TPR A0 0,5691 0,8381 -0,1252 0,209 0,385 0,285
TPR β 0,8061 0,7591 0,0852 0,123 0,486 0,400
TPR 0,8101 0,8381 -0,4011 0,164 0,425 0,210
Without personalization iof TPR
A0 β SV HR 0,007 -0,1621 0,046 0,171 0,126 0,342
SV HR -0,060 -0,012 0,014 0,165 0,129 0,253
HR 0,034 0,077 -0,020 0,122 0,189 0,177
SV -0,035 -0,073 0,019 0,167 0,161 0,252
A0 β 0,080 -0,226 0,051 0,092 0,181 0,301
A0 -0,1451 0,1501 -0,0922 0,113 0,120 0,283
β 0,2941 -0,2971 0,1372 0,086 0,195 0,365


Table 2. Simulation results for right brachial arterty and lower limbs. In total – 556 individuals

Parameters Correlations Mean relative error
Ps Pd Pp Ps Pd Pp
a. brachialis dextra
R A0 β SV HR 0,6811 0,7531 -0,0452 0,064 0,202 0,288
R SV HR 0,8171 0,8171 -0,120 0,051 0,164 0,205
a. tibialis posterior sinistra
R A0 β SV HR 0,6661 0,6441 0,0912 0,246 0,095 0,493
R SV HR 0,5721 0,6401 -0,001 0,187 0,093 0,346
a. tibialis posterior dextra
R A0 β SV HR 0,6161 0,6261 0,0872 0,248 0,098 0,492
R SV HR 0,5681 0,6501 -0,026 0,193 0,087 0,375

Table 3. Simulation results for different allometric equations used for minute output. All parameters were personalized: R, A0, β, SV, HR. In total – 556 individuals

Allometric equation Correlations Mean relative error
Ps Pd Pp Ps Pd Pp
0,7691 0,8481 -0,0002 0,054 0,199 0,343
0,7501 0,8311 -0,015 0,056 0,192 0,328
0,7821 0,8641 0,011 0,055 0,208 0,372
0,7591 0,8421 -0,006 0,055 0,197 0,338

Table 4. Simulation results with different model time. In each simulation last 2 seconds were used to obserev minimal and maximal ressures produced by the model

Model time Correlations Mean relative error
Ps Pd Pp Ps Pd Pp
6 секунд 0,7531 0,8671 0,031 0,058 0,197 0,364
12 секунд 0,7841 0,8641 0,011 0,055 0,208 0,372
20 секунд 0,7891 0,8621 0,008 0,055 0,209 0,373

Table 5. Simulation results for different age groups. Only TPR was personalized.

Age # Correlations Mean relative error
Ps Pd Pp Ps Pd Pp
<=30 24 0,9441 0,9641 0,257 0,043 0,195 0,306
(30,50] 42 0,8421 0,8841 0,121 0,032 0,152 0,231
(50,60] 178 0,8921 0,9371 -0,003 0,036 0,152 0,247
(60,70] 246 0,9081 0,9311 -0,010 0,040 0,162 0,289
(70,80] 181 0,8771 0,8961 -0,137 0,051 0,171 0,307

Table 6. Simulation results for control group (observation were recorded before 1 of May 1999)

Observation date # Correlations Mean relative error
Ps Pd Pp Ps Pd Pp
Before 01.05.1999 420 0,7331 0,8011 0,1112 0,073 0,199 0,335
After 01.05.1999 556 0,7841 0,8641 0,011 0,055 0,208 0,372
Any 976 0,7541 0,8361 0,098 0,062 0,205 0,356
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