View source for Flux balance analysis

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[https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3108565/ <b><i>Constraint-based flux balance analysis (FBA)</i></b>] is a mathematical approach that enables to provide a holistic view of the cellular metabolism in pro- and eukaryotes and predict flux distribution in a global (on a genome-scale level) metabolic network both under a range of environmental conditions and genetic perturbations. 
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==FBA via Diagram==

==FBA via Analysis tab==

[[File:fba1.png|thumb|FBC analysis view in the BioUML]]
In the [[BioUML]] it is represented in the [[Flux Balance Constraint (analysis)|Flux Balance Constraint]] analysis.
This page contains brief instruction of how this analysis should be used.

=== FBC analysis usage ===
[[File:fba2.png|thumb|Solver type choosing in the FBC analysis]]
[[File:fba4.png|thumb|Example of "FBC table" tab usage for Recon model]]
To start work with the [[Flux Balance Constraint (analysis)|Flux Balance Constraint]] analysis one needs a {{Type link|diagram}} and a special table with data about its fluxes (names, bounds, objective function coefficients, etc.). Analysis enables to select path to the {{Type link|diagram}}, to the data table and to the table with results. Also it has an expert mode where user can select type of the objective function, solver type (apache simplex solver and gurobi solver are available) and some solver's properties. If the {{Type link|diagram}} contains fluxes properties written as fbc extension of the SBML "FBC table" tab can be used. Advantage of this tab usage is lack of necessity in creation table with data about fluxes: it will be created automatically using {{Type link|diagram}}.

=== FBC data table creation ===
[[File:bfb1.png|thumb|View of Building Flux Balance Data Table analysis]]
Table with flux balance constraint data can be created via [[Building Flux Balance DataTable (analysis)|Building Flux Balance Data Table]] analysis.
It is worth noting, that the [[Building Flux Balance DataTable (analysis)|Building Flux Balance Data Table]] analysis and "FBC table" tab work only with [[SBML (file format)|SBML]] L3v1 {{Type link|diagram}}s with special fbc package. Thus if the {{Type link|diagram}} does not satisfy these conditions it should be transformed before using this analysis. For example, if the {{Type link|diagram}} does not use fbc package but contains all necessary information about fluxes, it should be firtsly preprocessed by [[Recon transformer (analysis)|Recon transformer]].