From BioUML platform
|long-term regulation of arterial pressure
|While the view that renal function is the dominant controller of arterial pressure has been supported by computer models of the cardiovascular system known as the “Guyton-Coleman model”, no unambiguous description of a computer model capturing chronic adaptation of acute renal function in blood pressure control has been presented. Here, such a model is developed with the goals of: 1. capturing the relevant mechanisms in an identifiable mathematical model; 2. identifying model parameters using appropriate data; 3. validating model predictions in comparison to data; and 4. probing hypotheses regarding the long-term control of arterial pressure and the etiology of primary hypertension. The developed model reveals: long-term control of arterial blood pressure is primarily through the baroreflex arc and the renin-angiotensin system; and arterial stiffening provides a sufficient explanation for the etiology of primary hypertension associated with ageing. Furthermore, the model provides the first consistent explanation of the physiological response to chronic stimulation of the baroreflex.
The model include 5 blocks:
|Virtual rat project
- Beard DA, Pettersen KH, Carlson BE et al. (2013) A computational analysis of the long-term regulation of arterial pressure [v1; ref status: approved 1, approved with reservations 1, http://f1000r.es/1xq] F1000Research 2013, 2:208 (doi: 10.12688/f1000research.2-208.v1)