Overall circulation model

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Overall Circulation model

The overall circulation model was created by Guyton and colleagues in 1972[1]. The model consists of differential-algebraic- equations and demonstrates long-term effects of CVS with significant role of kidney regulation. Despite the fact that a lot of time has passed since the model was published, it is still an object of interest for systems biologists[2]. In 2010 it was reconstructed using MATLAB SIMULINK[3]. A number of latest global models are also based on Guyton's model. One of such models is the long-term CVS model implemented by Karaaslan and coauthors[4].

We have reconstructed it as a modular model in the BioUML framework. The modular model comprises:

229 parameters 133 assignments 39 ordinary differential equations


  1. Guyton A. C., Coleman T. G., Granger H. J. Circulation: Overall regulation. Ann. Rev. Physiol. 1972; V. 34:. P. 13-46. doi:10.1146/annurev.ph.34.030172.000305
  2. Osborn J.W., Averina V.A., Fink G.D. Current computational models do not reveal the importance of the nervous system in long-term control of arterial pressure. Exp Physiol 94(4): 381-397, 2009. doi:10.1113/expphysiol.2008.043281
  3. Kofranek J., J. Rusz. Restoration of Guyton's diagram for regulation of the circulation as a basis for quantitative physiological model development. Physiological Research, 2010, 59(6): 897-908.
  4. Karaaslan F., Denizhan Y.,Kayserilioglu A., Gulcur H.O. Long-term mathematical model involving renal sympathetic nerve activity, arterial pressure, and sodium excretion // Ann. Biomed. Eng. 2005. Vol.33. P.1607 - 1630. doi:10.1007/s10439-005-5976-4
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