Analyze miRNA target enrichment (analysis)

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Analysis title
BSA-Analyze-miRNA-target-enrichment-icon.png Analyze miRNA target enrichment
Provider
geneXplain GmbH
Class
MirnaTargetAnalyzer
Plugin
com.genexplain.mirna (geneXplain micro-RNA)

Contents

Analyze micro-RNA target enrichment

Parameters

  • Input genes - Genes to analyze for miRNA target enrichment
  • miRNA/gene database - Database of miRNA/target gene links
  • Species - Species
  • Output path - Path for analysis results

Output

The output is a table of micro-RNAs showing their enrichment in the set of input genes. The result table comprises the number of input genes with at least one miRNA site, the adjusted fold enrichment, the P-value of enrichment, the FDR of enrichment, and the score cutoff with best enrichment.

The fold enrichment shows how much more frequent target genes for a miRNA are in the input gene set versus the entire set of database genes. Enrichment is further quantified by P-value (Fisher test) and FDR (Benjamini-Hochberg method).

The score is database specific, e.g. can be the TargetScan context score or the miRDB SVM score.

Description

This tool takes a set of Ensembl genes and a database of miRNA/target gene links as input and tests for enrichment of micro-RNA targets in the input genes.

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