Compare TFBS mutations (analysis)

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Analysis title
Mutations-Compare-TFBS-mutations-icon.png Compare TFBS mutations
Provider
Institute of Systems Biology
Class
CompareTFBSMutations
Plugin
ru.biosoft.bsa (Bio-sequences analyses plugin)

Description

Find transcription factors that have different proportions of site losses(gains) in two datasets.

Parameters:

  • Experiment VCF track – Experiment VCF track
  • Control VCF track – Control VCF track
  • Genome – Reference genome
    • Sequences source – Select database to get sequences from or 'Custom' to specify sequences location manually
    • Sequence collection – Specify path to folder containing sequences if 'Custom' sequences source is selected
  • Profile – Predefined set of site models
  • P-value cutoff – P-value cutoff
  • Input size limit – If the input VCF larger than this limit, the VCF track will be randomly subsampled to this size.
  • Site gains table – Table with transcription factors which change frequency of site gains between experiment and control
  • Site losses table – Table with transcription factors which change frequency of site losses between experiment and control
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