Virtual rat

The Virtual Physiological Rat Project aims to simulate the integrated cardiovascular function of the rat, and to build validated computer models that account for genetic variation across rat strains and physiological response to environment (i.e., diet). In addition, new strains of genetically engineered rat will be developed with the ultimate goal of using computer models to predict the physiological characteristics of not yet realized genetic combinations, derive those combinations in the lab, and then test the predictions.

http://virtualrat.org/

Main publications

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2. Beard DA, Pettersen KH, Carlson BE et al. (2013) A computational analysis of the long-term regulation of arterial pressure [v1; ref status: approved 1, approved with reservations 1, http://f1000r.es/1xq] F1000Research 2013, 2:208 (doi: 10.12688/f1000research.2-208.v1)

   we need to investigate/reproduce this model

3. Bugenhagen, SM. (2013) The Role of Metabolic Dysfunction in Heart Failure. Cardiac Physiome Workshop, Bar Harbor, ME, October 17, 2013.

   MS Power Point[1], contains a lot of interesting references