Overall circulation model - Revision history

Lan@dote.ru: DOI

2013-07-01T04:39:34Z

DOI

Lan@dote.ru: DOI

2013-07-01T04:36:58Z

DOI

Lan@dote.ru: Modular modeling link

2013-05-07T05:18:29Z

Modular modeling link

Lan@dote.ru: +Category:Modular modeling

2013-04-16T08:13:42Z

+Category:Modular modeling

Fkolpakov@gmail.com at 18:32, 4 April 2013

2013-04-04T18:32:23Z

Axec@dote.ru at 06:47, 4 April 2013

2013-04-04T06:47:00Z

Axec@dote.ru: Created page with "Overall Circulation model The overall circulation model was created by Guyton and colleagues in 1972 Guyton A. C., Coleman T. G., Granger H. J...."

2013-04-03T08:09:52Z

Created page with "Overall Circulation model The overall circulation model was created by Guyton and colleagues in 1972 <ref>Guyton A. C., Coleman T. G., Granger H. J...."

New page

[[File:guyton.png|thumb|Overall Circulation model]]

The overall circulation model was created by Guyton and colleagues in 1972 <ref>Guyton A. C., Coleman T. G., Granger H. J. Circulation: Overall regulation. Ann. Rev. Physiol. 1972; V. 34:. P. 13-46.</ref>. The model consists of differential-algebraic- equations and demonstrates long-term effects of CVS with significant role of kidney regulation. Despite the fact that a lot of time has passed since the model was published, it is still an object of interest for systems biologists (e.g., see <ref>Osborn J.W., Averina V.A., Fink G.D. Current computational models do not reveal the importance of the nervous system in long-term control of arterial pressure. Exp Physiol 94(4): 381-397, 2009.</ref>). In 2010 it was reconstructed using MATLAB SIMULINK <ref>Kofranek J., J. Rusz. Restoration of Guyton's diagram for regulation of the circulation as a basis for quantitative physiological model development. Physiological Research, 2010, 59(6): 897-908.</ref>. A number of latest global models are also based on Guyton's model. One of such models is the long-term CVS model implemented by Karaaslan and coauthors <ref>Karaaslan F., Denizhan Y.,Kayserilioglu A., Gulcur H.O. Long-term mathematical model involving renal sympathetic nerve activity, arterial pressure, and sodium excretion // Ann. Biomed. Eng. 2005. Vol.33. P.1607 - 1630.</ref>.

We have reconstructed it as a modular model in the BioUML framework. The modular model comprises:

229 parameters
133 assignments
39 ordinary differential equations

<references/>

@@ Line 1: / Line 1: @@
 [[File:guyton.png|thumb|Overall Circulation model]]
-The overall circulation model was created by Guyton and colleagues in 1972<ref>Guyton A. C., Coleman T. G., Granger H. J. Circulation: Overall regulation. Ann. Rev. Physiol. 1972; V. 34:. P. 13-46. {{doi|10.1146/annurev.ph.34.030172.000305}}</ref>. The model consists of differential-algebraic- equations and demonstrates long-term effects of CVS with significant role of kidney regulation. Despite the fact that a lot of time has passed since the model was published, it is still an object of interest for systems biologists<ref>Osborn J.W., Averina V.A., Fink G.D. Current computational models do not reveal the importance of the nervous system in long-term control of arterial pressure. Exp Physiol 94(4): 381-397, 2009.</ref>. In 2010 it was reconstructed using MATLAB SIMULINK<ref>Kofranek J., J. Rusz. Restoration of Guyton's diagram for regulation of the circulation as a basis for quantitative physiological model development. Physiological Research, 2010, 59(6): 897-908.</ref>. A number of latest global models are also based on Guyton's model. One of such models is the long-term CVS model implemented by Karaaslan and coauthors<ref>Karaaslan F., Denizhan Y.,Kayserilioglu A., Gulcur H.O. Long-term mathematical model involving renal sympathetic nerve activity, arterial pressure, and sodium excretion // Ann. Biomed. Eng. 2005. Vol.33. P.1607 - 1630. {{doi|10.1007/s10439-005-5976-4}}</ref>.
+The overall circulation model was created by Guyton and colleagues in 1972<ref>Guyton A. C., Coleman T. G., Granger H. J. Circulation: Overall regulation. Ann. Rev. Physiol. 1972; V. 34:. P. 13-46. {{doi|10.1146/annurev.ph.34.030172.000305}}</ref>. The model consists of differential-algebraic- equations and demonstrates long-term effects of CVS with significant role of kidney regulation. Despite the fact that a lot of time has passed since the model was published, it is still an object of interest for systems biologists<ref>Osborn J.W., Averina V.A., Fink G.D. Current computational models do not reveal the importance of the nervous system in long-term control of arterial pressure. Exp Physiol 94(4): 381-397, 2009. {{doi|10.1113/expphysiol.2008.043281}}</ref>. In 2010 it was reconstructed using MATLAB SIMULINK<ref>Kofranek J., J. Rusz. Restoration of Guyton's diagram for regulation of the circulation as a basis for quantitative physiological model development. Physiological Research, 2010, 59(6): 897-908.</ref>. A number of latest global models are also based on Guyton's model. One of such models is the long-term CVS model implemented by Karaaslan and coauthors<ref>Karaaslan F., Denizhan Y.,Kayserilioglu A., Gulcur H.O. Long-term mathematical model involving renal sympathetic nerve activity, arterial pressure, and sodium excretion // Ann. Biomed. Eng. 2005. Vol.33. P.1607 - 1630. {{doi|10.1007/s10439-005-5976-4}}</ref>.
 We have reconstructed it as a [[Modular modeling|modular model]] in the BioUML framework. The modular model comprises:

@@ Line 1: / Line 1: @@
 [[File:guyton.png|thumb|Overall Circulation model]]
-The overall circulation model was created by Guyton and colleagues in 1972<ref>Guyton A. C., Coleman T. G., Granger H. J. Circulation: Overall regulation. Ann. Rev. Physiol. 1972; V. 34:. P. 13-46.</ref>. The model consists of differential-algebraic- equations and demonstrates long-term effects of CVS with significant role of kidney regulation. Despite the fact that a lot of time has passed since the model was published, it is still an object of interest for systems biologists<ref>Osborn J.W., Averina V.A., Fink G.D. Current computational models do not reveal the importance of the nervous system in long-term control of arterial pressure. Exp Physiol 94(4): 381-397, 2009.</ref>. In 2010 it was reconstructed using MATLAB SIMULINK<ref>Kofranek J., J. Rusz. Restoration of Guyton's diagram for regulation of the circulation as a basis for quantitative physiological model development. Physiological Research, 2010, 59(6): 897-908.</ref>. A number of latest global models are also based on Guyton's model. One of such models is the long-term CVS model implemented by Karaaslan and coauthors<ref>Karaaslan F., Denizhan Y.,Kayserilioglu A., Gulcur H.O. Long-term mathematical model involving renal sympathetic nerve activity, arterial pressure, and sodium excretion // Ann. Biomed. Eng. 2005. Vol.33. P.1607 - 1630.</ref>.
+The overall circulation model was created by Guyton and colleagues in 1972<ref>Guyton A. C., Coleman T. G., Granger H. J. Circulation: Overall regulation. Ann. Rev. Physiol. 1972; V. 34:. P. 13-46. {{doi|10.1146/annurev.ph.34.030172.000305}}</ref>. The model consists of differential-algebraic- equations and demonstrates long-term effects of CVS with significant role of kidney regulation. Despite the fact that a lot of time has passed since the model was published, it is still an object of interest for systems biologists<ref>Osborn J.W., Averina V.A., Fink G.D. Current computational models do not reveal the importance of the nervous system in long-term control of arterial pressure. Exp Physiol 94(4): 381-397, 2009.</ref>. In 2010 it was reconstructed using MATLAB SIMULINK<ref>Kofranek J., J. Rusz. Restoration of Guyton's diagram for regulation of the circulation as a basis for quantitative physiological model development. Physiological Research, 2010, 59(6): 897-908.</ref>. A number of latest global models are also based on Guyton's model. One of such models is the long-term CVS model implemented by Karaaslan and coauthors<ref>Karaaslan F., Denizhan Y.,Kayserilioglu A., Gulcur H.O. Long-term mathematical model involving renal sympathetic nerve activity, arterial pressure, and sodium excretion // Ann. Biomed. Eng. 2005. Vol.33. P.1607 - 1630. {{doi|10.1007/s10439-005-5976-4}}</ref>.
 We have reconstructed it as a [[Modular modeling|modular model]] in the BioUML framework. The modular model comprises:

@@ Line 3: / Line 3: @@
 The overall circulation model was created by Guyton and colleagues in 1972<ref>Guyton A. C., Coleman T. G., Granger H. J. Circulation: Overall regulation. Ann. Rev. Physiol. 1972; V. 34:. P. 13-46.</ref>. The model consists of differential-algebraic- equations and demonstrates long-term effects of CVS with significant role of kidney regulation. Despite the fact that a lot of time has passed since the model was published, it is still an object of interest for systems biologists<ref>Osborn J.W., Averina V.A., Fink G.D. Current computational models do not reveal the importance of the nervous system in long-term control of arterial pressure. Exp Physiol 94(4): 381-397, 2009.</ref>. In 2010 it was reconstructed using MATLAB SIMULINK<ref>Kofranek J., J. Rusz. Restoration of Guyton's diagram for regulation of the circulation as a basis for quantitative physiological model development. Physiological Research, 2010, 59(6): 897-908.</ref>. A number of latest global models are also based on Guyton's model. One of such models is the long-term CVS model implemented by Karaaslan and coauthors<ref>Karaaslan F., Denizhan Y.,Kayserilioglu A., Gulcur H.O. Long-term mathematical model involving renal sympathetic nerve activity, arterial pressure, and sodium excretion // Ann. Biomed. Eng. 2005. Vol.33. P.1607 - 1630.</ref>.
-We have reconstructed it as a modular model in the BioUML framework. The modular model comprises:
+We have reconstructed it as a [[Modular modeling|modular model]] in the BioUML framework. The modular model comprises:
 parameters

← Older revision		Revision as of 08:13, 16 April 2013
Line 13:		Line 13:

	[[Category:Cardiovascular system]]		[[Category:Cardiovascular system]]
		+	[[Category:Modular modeling]]

← Older revision		Revision as of 18:32, 4 April 2013
Line 11:		Line 11:
	==References==		==References==
	<references/>		<references/>
		+
		+	[[Category:Cardiovascular system]]