Modular model of the human CVS v.1 - Revision history

Lan@dote.ru: DOI

2013-07-01T04:37:30Z

DOI

Lan@dote.ru: +Category:Modular modeling

2013-04-16T08:14:02Z

+Category:Modular modeling

Fkolpakov@gmail.com at 18:31, 4 April 2013

2013-04-04T18:31:45Z

Axec@dote.ru at 09:51, 3 April 2013

2013-04-03T09:51:57Z

Axec@dote.ru at 09:51, 3 April 2013

2013-04-03T09:51:31Z

Axec@dote.ru: Created page with "Overall Circulation model Using the modular approach we have created a complex modular model of the human cardiovascular..."

2013-04-03T09:35:49Z

Created page with "Overall Circulation model Using the modular approach we have created a complex modular model of the human cardiovascular..."

New page

[[File:modular_cvs_1.png|thumb|Overall Circulation model]]

Using the [[Modular modeling|modular approach]] we have created a complex modular model of the human cardiovascular system (CVS) on the basis of:
*[[Long-term model of the CVS/Renal system]] by Karaaslan et al. <ref>Karaaslan F., Denizhan Y.,Kayserilioglu A., Gulcur H.O. Long-term mathematical model involving renal sympathetic nerve activity, arterial pressure, and sodium excretion // Ann. Biomed. Eng. 2005. Vol.33. P.1607 - 1630.</ref>
*[[Short term model of the heart output regulation]] cerated by professor Soloyannikov. <ref>Solodyannikov Y.V. The elements or mathematical modeling and hemodynamics system identification. Samara: The university of Samara, 1994.</ref>
The models have the same formalisms - ordinary differential equations with descrete events, however they have different time scales: seconds in the short-term model, minutes in the long-term one. Merge of the models was based on the next two points: The "Heart" and "Arteris" modules from the long-term modular model contain the averaged parameters such as arterial blood pressure or arterial resistance described in more detail by the short-term model, in its turn, the long-term human CVS model contains a blood volume regulation mechanism based on the salt-water balance in the human body, while the short-term model keeps the blood volume parameter at a constant level. The established connections between the modules were taken from different models:

Arterial pressure PA and cardiac output Vout from the short-term model are passed to the long-term model (after the averaging to avoid systole-diastole oscillations)
Blood volume VSyst is passed to the short-term model

==References==
<references/>

← Older revision		Revision as of 08:14, 16 April 2013
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	[[Category:Cardiovascular system]]		[[Category:Cardiovascular system]]
		+	[[Category:Modular modeling]]

← Older revision		Revision as of 18:31, 4 April 2013
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	==References==		==References==
	<references/>		<references/>
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		+	[[Category:Cardiovascular system]]

← Older revision		Revision as of 09:51, 3 April 2013
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−	[[File:modular_cvs_1.png\|thumb\|Overall Circulation model]]	+	[[File:modular_cvs_1.png\|thumb\|Overall Circulation modular model]]
	[[File:simulation_example.png\|thumb\|Simulation example: sodium load]]		[[File:simulation_example.png\|thumb\|Simulation example: sodium load]]

← Older revision		Revision as of 09:51, 3 April 2013
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	[[File:modular_cvs_1.png\|thumb\|Overall Circulation model]]		[[File:modular_cvs_1.png\|thumb\|Overall Circulation model]]
		+	[[File:simulation_example.png\|thumb\|Simulation example: sodium load]]

	Using the [[Modular modeling\|modular approach]] we have created a complex modular model of the human cardiovascular system (CVS) on the basis of:		Using the [[Modular modeling\|modular approach]] we have created a complex modular model of the human cardiovascular system (CVS) on the basis of:

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 Using the [[Modular modeling|modular approach]] we have created a complex modular model of the human cardiovascular system (CVS) on the basis of:
-*[[Long-term model of the CVS/Renal system]] by Karaaslan et al. <ref>Karaaslan F., Denizhan Y.,Kayserilioglu A., Gulcur H.O. Long-term mathematical model involving renal sympathetic nerve activity, arterial pressure, and sodium excretion // Ann. Biomed. Eng. 2005. Vol.33. P.1607 - 1630.</ref>
+*[[Long-term model of the CVS/Renal system]] by Karaaslan et al. <ref>Karaaslan F., Denizhan Y.,Kayserilioglu A., Gulcur H.O. Long-term mathematical model involving renal sympathetic nerve activity, arterial pressure, and sodium excretion // Ann. Biomed. Eng. 2005. Vol.33. P.1607 - 1630. {{doi|10.1007/s10439-005-5976-4}}</ref>
 *[[Short term model of the heart output regulation]] cerated by professor Soloyannikov. <ref>Solodyannikov Y.V. The elements or mathematical modeling and hemodynamics system identification. Samara: The university of Samara, 1994.</ref>
 The models have the same formalisms - ordinary differential equations with descrete events, however they have different time scales: seconds in the short-term model, minutes in the long-term one. Merge of the models was based on the next two points: The "Heart" and "Arteris" modules from the long-term modular model contain the averaged parameters such as arterial blood pressure or arterial resistance described in more detail by the short-term model, in its turn, the long-term human CVS model contains a blood volume regulation mechanism based on the salt-water balance in the human body, while the short-term model keeps the blood volume parameter at a constant level. The established connections between the modules were taken from different models: